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Aspirin poisoning [ edit ]
| Aspirin poisoning | |
|---|---|
| Synonym | Salicylism, salicylate toxicity, salicylate poisoning, aspirin toxicity, aspirin overdose |
 | |
| Aspirin perspective structural formula | |
| Medical specialties | Emergency medicine |
| symptom | Tinnitus , nausea , abdominal pain , excessive breathing [1] |
| complication | Brain edema , pulmonary edema,epilepsy , hypoglycemia , cardiac arrest [1] |
| diagnosis method | Early : Aspirin is slightly overdose with a blood level of 2.2 mmol/L (30 mg/dL, 300 mg/L),respiratory alkalosis [1] Late : metabolic acidosis [1] |
| Similar diseases or comorbidities | Sepsis , myocardial infarction , and mental agitation [1] |
| prevention | Anti-gestation packaging : less pills in each bottle [1] |
| treatment | Activated carbon ,bisphosphonate mixed syrup orpotassium chloride , hemodialysis [2] |
| Prognosis | About 1% death chance [3] |
| Prevalence rate | Each year in the United States is greater than 20,000 [1] |
Aspirin poisoning, also known as salicylate poisoning , refers to acute or chronic salicylate poisoning, mostly aspirin . [1] The most common symptoms are tinnitus , nausea, abdominal pain, and shortness of breath to compensate for acidosis . [1] These symptoms may not be apparent at an early stage, and fever may appear as the dose rises. [1] [4] Complications include cerebral edema , pulmonary edema, epilepsy , hypoglycemia , and may even lead to cardiac arrest. [1]
The most common cause of salicylate poisoning is aspirin poisoning, and other possible reasons are winter oil or salicyclic salicylate. [2] Excessive doses are most likely caused by accidental or deliberate use. [1] A small amount of wintergreen oil is very likely to cause poisoning. [2] The method of diagnosing poisoning is to repeat the blood test to check the concentration of salicylic acid and monitor the pH of arterial blood. [1] Although some people use the nomogram to help diagnose, but does not require routine use. [1] The highest dose of salicylic acid in blood does not last longer than 12 hours. [2]
There are currently many measures to avoid salicylate poisoning: use packages that prevent children from eating infrequently, with fewer grains in each bottle and avoid eating in large quantities. [1]Treatment includes the use of activated carbon , bisphosphonates intravenously mixed with sugar syrup, potassium chloride, and hemodialysis. [2] Giving sugar water can help salicylic acid poisoning even if blood sugar is normal. [2] Hemodialysis is recommended for patients with renal failure, unconsciousness, blood pH values below 7.2, or high blood salicylic acid concentrations. [2] If someone has shortness of breath, consider the possibility of intubation. [1]
The earliest in 1877, the literature has described the phenomenon of salicylic acidosis. [5] In 2004, more than 20,000 cases occurred in the United States, resulting in 43 deaths. [1] Nearly 1% of cases of acute poisoning eventually led to death, while chronic poisoning was even more severe. [3] Older people are more likely to be poisoned than other age groups. [5]
References [ edit ]
- ^ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 O'Malley, GF. Emergency department management of the salicylate-poisoned patient.. emergency medicine clinics of North America. May 2007, 25 ( 2): 333–46; abstract viii. PMID 17482023 .
- ^ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Walls, Ron. Rosens Emergency Medicine Concepts and Clinical Practice 9th. Elsevier. 2017: X. ISBN 978-0323354790 .
- ^ 3.0 3.1 McNeil Consumer & Specialty Pharmaceuticals. Assessment of Safety of aspirin and other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) . FDA. 2002 [ 27 June 2017] .
- ^ Brenner, George M.; Stevens, Craig. Pharmacology E-Book: with STUDENT CONSULT Online Access 4. Elsevier Health Sciences. 2012: 319. ISBN 1455702781 (English) .
- ^ 5.0 5.1 Roland, Peter S .; Rutka, John A. Ototoxicity . PmpH-USA 2004:. 28 [ 27 June 2017] . ISBN 9,781,550,092,639 (English) .
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